Intense F-18 FDG Uptake in the Stomach Wall in Follicular Gastritis in Zollinger-Ellison Syndrome.
Clin Nucl Med. 2007 Feb;32(2):150-1.
Basu S., Nair N.
From the Radiation Medicine Centre, Bhabha Atomic Research Centre, Bombay, India.
A 59-year-old woman, who had surgery for a suspected pancreatic tumor and was detected to have a gastrinoma, was referred for F-18 FDG PET for disease evaluation. Whole-body FDG PET showed diffuse intense FDG PET uptake (SUVmax 5.44) throughout the stomach. The patient was asked to drink a large amount of water and a repeat spot FDG PET (limited to the surface marking of the stomach) was acquired. The uptake was mildly reduced (SUVmax 4.75) but persisted in the distended stomach wall. An endoscopic biopsy from the antrum and fundus revealed follicular gastritis with erosion. The biopsy was negative for neoplasm. The patient was thought to have gastritis in a Zollinger-Ellison syndrome. Varying degrees of FDG uptake in the stomach have been described in certain benign conditions. Gastritis secondary to Zollinger-Ellison syndrome should be included in the differential diagnosis of diffuse intense gastric uptake, when such a history is present in the patient
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Gastric Distension by Ingesting Food Is Useful in the Evaluation of Primary Gastric Cancer by FDG PET.
Clin Nucl Med. 2007 Feb;32(2):106-109.
Zhu Z., Li F., Zhuang H.
From the *Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; and the daggerDepartment of Radiology, the Children's Hospital of Philadelphia, Philadelphia, PA.
Gastric carcinoma is the second leading cause of cancer-related death worldwide. Detection and surgical resection of gastric cancer in the early stage provides the only hope for improved survival in patients with gastric cancer. Positron emission tomography (PET) with F-18 2-deoxy-2-fluoro-D-glucose (FDG) has been shown to be essential in the evaluation of a variety of malignancies. However, conventional FDG PET has limited value for detecting a primary tumor of the stomach, mostly because of the relatively high levels of physiological uptake by the contracted stomach. We report 3 cases of primary gastric carcinomas detected successfully by FDG PET after the ingestion of food. The PET images of the stomach after ingesting food were compared with the routine fasting-state whole-body PET images for each patient. When the stomach was distended by food, the malignant lesions were more discernible. These cases indicate that gastric distension by ingesting food may be a simple method that can help to detect a primary gastric malignancy by FDG PET.
Enviado por: Antonio Maldonado (3/2/07)
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